Biochem/physiol Actions

Reversible: no

Product does not compete with ATP.

Cell permeable: yes

Primary TargetExhibits enhanced fluorescence upon binding to amyloid fibrils

General description

A cell-permeable benzothiazole dye that exhibits enhanced fluorescence upon binding to amyloid fibrils. Useful in monitoring stacked β sheet aggregates. Associates with aggregated fibrils of synthetic β/A4-derived peptides β(1-28) and β(1-40), resulting in a shift in the excitation maximum and an enhanced emission. Excitation max.: ~385 nm (free); ~437 nm (bound); emission max.: ~445 nm (free); ~485 nm (bound).

A cell-permeable benzothiazole dye that exhibits enhanced fluorescence upon binding to amyloid fibrils. Useful in monitoring stacked β sheet aggregates.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Tjernberg, L.O., et al. 1999. J. Biol. Chem.274, 12619.Naiki, H. and Nakakuki, K. 1996. Lab. Invest.74, 374.LeVine, H. 1993. Protein Sci.2, 404.

Packaging

Packaged under inert gas

500 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Warning

Toxicity: Standard Handling (A)